Quality results define us
AnproTech provides comprehensive biological and immunological solutions to help academic researchers and leading biopharmaceutical companies achieve greater success.
Global Provider of Contract Research
ACCOUNTABILITY - INTEGRITY - TENACITY
AnproTech has a long and successful history of antibody discovery and engineering, to overcome a wide range of our clients' challenges to accelerate their antibody drug development pipelines. AnproTech's portfolio of contract research services offer a range of standard and customized packages, which include Antibody discovery by hybridoma cells, Single B cell cloning and synthetic human antibody library screening; Antibody engineering includes bi-specific antibody, antibody humanization and affinity maturation; Developability of biological leads; CMC optimization and development on biological leads; Reagent / GLP / GMP biological production; Preclinical studies. AnproTech continually builds up a wide range of services with an aim to help our clients to achieve each milestone quickly and efficiently. Since 2004, the quality results of each service delivered by AnproTech meets the reality for potentially curing patients.
Synthetic Full Human Antibody Library
SFHAL SERVICE
AnproTech’s SFHAL phage library contains billions of functional human antibody V domain genes for screening therapeutic antibody hits. The diversity of SFHAL’s synthetic full human antibody clones have been designed and developed to exceed human antibodies made by nature. The frame of each human antibody clone are CMC optimized for further manufacture with high expression yield (＞2 g/L).
SFHAL is based on a set of modular antibody frames with highly diversified CDRs. It was created by a bioinformatics and machine learning approach – the diversity of SFHAL has been expanding by every single day to ensure the continuing affinity maturation of each clone. SFHAL’s master V domain genes are prepared from human B cell germline genes and are therefore fully human, so no humanization is necessary. The V domain sequences of each selected antibody candidate is known and each antibody candidate can be produced in designed human full length antibody in isotypes / Fab format, which leads to a secured, consistent and stable batch-to-batch supply from research grade to cGMP grade.
Develop-ability of deliverables
SFHAL service deliverables
Client will own property rights of V-domain sequence (DNA and amino acid sequences), recombinant scFv and recombinant antibody of each human antibody clone delivered by AnproTech Inc. after all service payments are made by client.
